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Papers of the Week

Papers: 20 Apr 2019 - 26 Apr 2019

Human Studies

2019 Apr 20

BMJ Open



Genetic components of human pain sensitivity: a protocol for a genome-wide association study of experimental pain in healthy volunteers.


Schmid AB, Adhikari K, Ramirez-Aristeguieta L M, Chacón-Duque J-C, Poletti G, Gallo C, Rothhammer F, Bedoya G, Ruiz-Linares A, Bennett DL
BMJ Open. 2019 Apr 20; 9(4):e025530.
PMID: 31005922.


Pain constitutes a major component of the global burden of diseases. Recent studies suggest a strong genetic contribution to pain susceptibility and severity. Whereas most of the available evidence relies on candidate gene association or linkage studies, research on the genetic basis of pain sensitivity using genome-wide association studies (GWAS) is still in its infancy. This protocol describes a proposed GWAS on genetic contributions to baseline pain sensitivity and nociceptive sensitisation in a sample of unrelated healthy individuals of mixed Latin American ancestry.