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Papers of the Week

Papers: 13 Apr 2019 - 19 Apr 2019

Animal Studies

2019 Jun

Neurourol Urodyn



Neuregulin-1-ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide-induced cystitis.


Chen J-L, Zhou X, Ding H-L, Zhan H-L, Yang F, Li W-B, Xie J-C, Liu X-G, Xu Y-C, Su M-Z, Liu B-L, Zhou X-F
Neurourol Urodyn. 2019 Jun; 38(5):1250-1260.
PMID: 30989724.


Central sensitization playsimportant roles in cyclophosphamide (CYP)-induced cystitis. In addition, as a visceral pain, CYP-induced chronic pain shares common pathophysiological mechanisms with neuropathic pain. Previous studies demonstrated that neuregulin-1 (Nrg1)-ErbB signaling contributes to neuropathic pain, but whether and how this signaling influences mechanical allodynia in CYP-induced cystitis is unclear. This study aimed to determine whether and how Nrg1-ErbB signaling modulates mechanical allodynia in a CYP-induced cystitis rat model.