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Recent Pat Biotechnol



The Effect of Alpha-Tocopherol on Morphine Tolerance-induced Expression of c-fos Proto-oncogene from a Biotechnological Perspective.


Mehrabi S, Nasirinezhad F, Barati M, Abutaleb N, Barati S, Dereshky B T, Amini N, Milan P B, Jahanmahin A, Sarveazad A, Samadikuchaksaraei A, Mozafari M
Recent Pat Biotechnol. 2019; 13(2):137-148.
PMID: 30973107.


The increase of oxidant compounds is the most well-known reasons for the tolerance to the analgesic properties of Morphine. Additionally, the production of proxy-nitrite impairs receptors, proteins and enzymes involved in the signaling pathways of analgesia, apoptosis and necrosis. Also, we revised all patents relating to opioid tolerance control methods.