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Papers of the Week

Papers: 13 Apr 2019 - 19 Apr 2019

Animal Studies, Pharmacology/Drug Development

2019 Jun

Future Med Chem



Molecular modeling and biological studies show that some μ-opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors.


Ronsisvalle S, Spadaro A, Tomasello B, Basile L, Panarello F, Franchini S, Renis M, Guccione S, Crascì L, Panico A M
Future Med Chem. 2019 Jun; 11(11):1245-1258.
PMID: 30974972.


Despite the serious side effects, analgesics acting on opioid receptors are still considered the best way to get antinociception. Matrix metalloproteinases, a large family of zinc-dependent proteases implicated in many pathological conditions, such as diabetes and osteoarthritis, are also involved in inflammation and pain. Methodology & results: Looking for evidence of possible interactions of opioid pathways and inflammation mediators, molecular modeling studies of a series of recently developed μ-opioid receptor benzomorphanic agonists together with biological data on pain and inflammation molecular targets, allowed us to hypothesize a possible correlation between μ-opioid receptor system and MMP-9.