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Papers of the Week


Papers: 13 Apr 2019 - 19 Apr 2019

RESEARCH TYPE:
Psychology


Animal Studies


2019 Apr 11


BMC Neurosci


20


1

Affective and cognitive behavior is not altered by chronic constriction injury in B7-H1 deficient and wildtype mice.

Authors

Karl F, Colaço M NB, Schulte A, Sommer C, Üçeyler N
BMC Neurosci. 2019 Apr 11; 20(1):16.
PMID: 30975083.

Abstract

Chronic neuropathic pain is often associated with anxiety, depressive symptoms, and cognitive impairment with relevant impact on patients` health related quality of life. To investigate the influence of a pro-inflammatory phenotype on affective and cognitive behavior under neuropathic pain conditions, we assessed mice deficient of the B7 homolog 1 (B7-H1), a major inhibitor of inflammatory response.