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Papers of the Week

Papers: 13 Apr 2019 - 19 Apr 2019

Animal Studies

2019 Apr 11

J Neuroinflammation



GPR34 in spinal microglia exacerbates neuropathic pain in mice.


Sayo A, Konishi H, Kobayashi M, Kano K, Kobayashi H, Hibi H, Aoki J, Kiyama H
J Neuroinflammation. 2019 Apr 11; 16(1):82.
PMID: 30975169.


Neuropathic pain is caused by sensory nerve injury, but effective treatments are currently lacking. Microglia are activated in the spinal dorsal horn after sensory nerve injury and contribute to neuropathic pain. Accordingly, molecules expressed by these cells are considered potential targets for therapeutic strategies. Our previous gene screening study using a mouse model of motor nerve injury showed that the G-protein-coupled receptor 34 gene (GPR34) is induced by nerve injury. Because GPR34 is now considered a microglia-enriched gene, we explored the possibility that it might be involved in microglial activation in the dorsal horn in a mouse model of neuropathic pain.