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Papers of the Week

2019 Apr 11

J Neuroinflammation



Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain.


Zhou D, Zhang S, Hu L, Gu Y-F, Cai Y, Wu D, Liu W-T, Jiang C-Y, Kong X, Zhang G-Q
J Neuroinflammation. 2019 Apr 11; 16(1):83.
PMID: 30975172.


Neuropathic pain is a serious clinical problem that needs to be solved urgently. ASK1 is an upstream protein of p38 and JNK which plays important roles in neuroinflammation during the induction and maintenance of chronic pain. Therefore, inhibition of ASK1 may be a novel therapeutic approach for neuropathic pain. Here, we aim to investigate the effects of paeoniflorin on ASK1 and neuropathic pain.