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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model.

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Papers: 6 Apr 2019 - 12 Apr 2019


Animal Studies

PAIN TYPE:
Migraine/Headache


2019 Apr 10


J Neuroinflammation


http://www.ncbi.nlm.nih.gov/pubmed/30971286?dopt=Abstract


16


1

Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model.

Authors

Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model.
He W, Long T, Pan Q, Zhang S, Zhang Y, Zhang D, Qin G, Chen L, Zhou J
J Neuroinflammation. 2019 Apr 10; 16(1):78.
PMID: 30971286.

Abstract

Central sensitization is an important mechanism of chronic migraine (CM) and is related to the inflammatory response of microglia. The NOD-like receptor protein 3 (NLRP3) inflammasome may regulate the inflammatory process of microglia in several neurological diseases, but its role in CM is largely unknown. Therefore, the aim of this study was to identify the precise role of microglial NLRP3 in CM.
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