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Papers of the Week

Papers: 6 Apr 2019 - 12 Apr 2019

Human Studies

2020 Jan




Magnetic Resonance Imaging Exploration of the Human Brain During 10 kHz Spinal Cord Stimulation for Failed Back Surgery Syndrome: A Resting State Functional Magnetic Resonance Imaging Study.


De Groote S, Goudman L, Peeters R, Linderoth B, Van Schuerbeek P, Sunaert S, De Jaeger M, De Smedt A, Moens M
Neuromodulation. 2020 Jan; 23(1):46-55.
PMID: 30974016.


Apart from the clinical efficacy of high frequency spinal cord stimulation at 10 kHz, the underlying mechanism of action remains unclear. In parallel with spinal or segmental theories, supraspinal hypotheses have been recently proposed. In order to unveil hidden altered brain connectome patterns, a resting state functional magnetic resonance imaging (rsfMRI) protocol was performed in subjects routinely treated for back and/or leg pain with high-frequency spinal cord stimulation (HF-SCS) HF-SCS at 10 kHz.