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Papers of the Week

Papers: 6 Apr 2019 - 12 Apr 2019

Animal Studies, Pharmacology/Drug Development

2019 Aug

Spine J



Administration of ONO-2506 suppresses neuropathic pain after spinal cord injury by inhibition of astrocytic activation.


Ishiguro H, Kaito T, Hashimoto K, Kushioka J, Okada R, Tsukazaki H, Kodama J, Bal Z, Ukon Y, Takenaka S, Makino T, Sakai Y, Yoshikawa H
Spine J. 2019 Aug; 19(8):1434-1442.
PMID: 30974239.


Spinal cord injury (SCI) results in not only motor dysfunction but also chronic neuropathic pain. Allodynia, an abnormal sensation that evokes pain against non-noxious stimuli, is a major symptom of post-SCI neuropathic pain. Astrocytic activation is a cause of post-SCI neuropathic pain and is considered a key treatment target. However, no effective treatment for these problems is available to date. ONO-2506 is a novel agent that suppresses astrocytic activation by inhibition of S100B production from astrocytes. Recently, it has been demonstrated that ONO-2506 inhibits secondary injury and improves motor function after SCI.