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Papers of the Week

Papers: 6 Apr 2019 - 12 Apr 2019

Animal Studies

2019 Sep

CNS Neurosci Ther



CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model.


Liu Z-Y, Song Z-W, Guo S-W, He J-S, Wang S-Y, Zhu J-G, Yang H-L, Liu J-B
CNS Neurosci Ther. 2019 Sep; 25(9):922-936.
PMID: 30955244.


Previous studies have demonstrated that the CXCL12/CXCR4 signaling axis is involved in the regulation of neuropathic pain (NP). Here, we performed experiments to test whether the CXCL12/CXCR4 signaling pathway contributes to the pathogenesis of neuropathic pain after spinal nerve ligation (SNL) via central sensitization mechanisms.