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Papers of the Week

2019 Sep

Spine (Phila Pa 1976)



Paraoxonase 1 (PON1) was Negatively Associated with Intervertebral Disc Degeneration (IVDD).


Chen F, Liu H, Li Z, Pei Y, Wang H, Zhang J, Wang J, Zheng Z
Spine (Phila Pa 1976). 2019 Sep; 44(18):E1053-E1062.
PMID: 30946296.


MINI: Paraoxonase 1 (PON1) is an enzyme with anti-inflammatory and anti-oxidative effects. Expression of PON1 is suppressed in degenerated discs and degenerative NP cell models. Knockdown of PON1 showed increased inflammatory and oxidative stress levels and decreased extracellular matrix levels in NP cells. PON1 might be a target for IVDD treatment.