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Papers of the Week
Paraoxonase 1 (PON1) was Negatively Associated with Intervertebral Disc Degeneration (IVDD).
Authors
Abstract
MINI: Paraoxonase 1 (PON1) is an enzyme with anti-inflammatory and anti-oxidative effects. Expression of PON1 is suppressed in degenerated discs and degenerative NP cell models. Knockdown of PON1 showed increased inflammatory and oxidative stress levels and decreased extracellular matrix levels in NP cells. PON1 might be a target for IVDD treatment.