I am a
Home I AM A Search Login

Papers of the Week

Papers: 6 Apr 2019 - 12 Apr 2019

Human Studies

2019 Aug

Br J Anaesth



Identifying brain regions associated with the neuropathology of chronic low back pain: a resting-state amplitude of low-frequency fluctuation study.


Zhang B, Jung M, Tu Y, Gollub R, Lang C, Ortiz A, Park J, Wilson G, Gerber J, Mawla I, Chan S-T, Wasan A, Edwards R, Lee J, Napadow V, Kaptchuk T, Rosen B, Kong J
Br J Anaesth. 2019 Aug; 123(2):e303-e311.
PMID: 30948036.


Previous studies have found widespread pain processing alterations in the brain in chronic low back pain (cLBP) patients. We aimed to (1) identify brain regions showing altered amplitude of low-frequency fluctuations (ALFF) using MRI and use these regions to discriminate cLBP patients from healthy controls (HCs) and (2) identify brain regions that are sensitive to cLBP pain intensity changes.