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Papers of the Week


Papers: 30 Mar 2019 - 5 Apr 2019


Human Studies, Pharmacology/Drug Development


2019 Sep


Curr Med Res Opin


35


9

Assessment of potentially abuse-related events in two phase 3 studies of NKTR-181, a novel opioid analgesic, using the MADDERS® system (Misuse, Abuse, and Diversion Drug Event Reporting System).

Authors

Lanier RK, Henningfield JE, Gudin J, Rauck R, Elder H, Erpelding N, Treister R, Gimbel J, Tagliaferri M, Doberstein SK, Di Fonzo CJ, Lu L, Siddhanti S, Katz NP
Curr Med Res Opin. 2019 Sep; 35(9):1513-1522.
PMID: 30932719.

Abstract

To prospectively evaluate the abuse potential of NKTR-181, a novel opioid analgesic, in two phase 3 clinical trials using a newly developed reporting system: the Misuse, Abuse, and Diversion Drug Event Reporting System (MADDERS®).