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Papers of the Week

Papers: 23 Mar 2019 - 29 Mar 2019

Human Studies, Pharmacology/Drug Development

2019 Aug

Br J Anaesth



Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABA partial agonist, in humans.


van Amerongen G, Siebenga PS, Gurrell R, Dua P, Whitlock M, Gorman D, Okkerse P, Hay JL, Butt RP, Groeneveld G J
Br J Anaesth. 2019 Aug; 123(2):e194-e203.
PMID: 30915991.


This study investigated the analgesic effects of two doses (15 and 65 mg) of PF-06372865, a novel α2/α3/α5 gamma-aminobutyric acid A (GABA) subunit selective partial positive allosteric modulator (PAM), compared with placebo and pregabalin (300 mg) as a positive control.