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Papers of the Week

Papers: 23 Mar 2019 - 29 Mar 2019

Human Studies, Pharmacology/Drug Development

2020 Apr 01

Pain Med



Paracetamol and Pain Modulation by TRPV1, UGT2B15, SULT1A1 Genotypes: A Randomized Clinical Trial in Healthy Volunteers.


Pickering G, Creveaux I, Macian N, Pereira B
Pain Med. 2020 Apr 01; 21(4):661-669.
PMID: 30908574.


The influence of the genetic polymorphism of enzymes and receptors involved in paracetamol metabolism and mechanism of action has not been investigated. This trial in healthy volunteers investigated the link between paracetamol pain relief and the genetic polymorphism of 23 enzymes and receptors.