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Papers of the Week

2019 Mar 21

J Neuroinflammation



Visualizing neuroinflammation with fluorescence and luminescent lanthanide-based in situ hybridization.


Parker LM, Sayyadi N, Staikopoulos V, Shrestha A, Hutchinson MR, Packer NH
J Neuroinflammation. 2019 Mar 21; 16(1):65.
PMID: 30898121.


Neurokine signaling via the release of neurally active cytokines arises from glial reactivity and is mechanistically implicated in central nervous system (CNS) pathologies such as chronic pain, trauma, neurodegenerative diseases, and complex psychiatric illnesses. Despite significant advancements in the methodologies used to conjugate, incorporate, and visualize fluorescent molecules, imaging of rare yet high potency events within the CNS is restricted by the low signal to noise ratio experienced within the CNS. The brain and spinal cord have high cellular autofluorescence, making the imaging of critical neurokine signaling and permissive transcriptional cellular events unreliable and difficult in many cases.