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Papers of the Week

2019 Mar

Clin Case Rep



Severe headache in primary Sjögren’s syndrome treated with intrathecal rituximab.


Tjensvoll A B, Lauvsnes M B, Norheim K B, Omdal R
Clin Case Rep. 2019 Mar; 7(3):416-418.
PMID: 30899462.


A severe and persistent migrainous headache in a patient with primary Sjøgren's syndrome unresponsive to treatment with immunosuppressive drugs, triptans, opioids, and NSAIDs, responded successfully to intrathecal B-cell depletion with rituximab. We hypothesize that brain-resident autoreactive B cells were involved in headache pathogenesis and were eliminated by this procedure.