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Papers of the Week

Papers: 23 Mar 2019 - 29 Mar 2019

Animal Studies

2019 Jan-Dec

Mol Pain


Calcium-stimulated adenylyl cyclase subtype 1 is required for presynaptic long term potentiation in the insular cortex of adult mice.



Recent studies indicate that presynaptic long-term potentiation (pre-LTP) in the anterior cingulate cortex (ACC) may contribute to chronic pain-related anxiety. In addition to the ACC, the insular cortex (IC) has also been indicated in chronic pain and its related emotional disorders. In the present study, we used a 64-channel multielectrode dish (MED64) system to record pre-LTP in the IC. We showed that low-frequency stimulation paired with a GluK1-containing kainate receptor agonist induced NMDA receptor-independent pre-LTP in the IC of wide-type (WT) mice. This form of pre-LTP was blocked in the IC of adenylyl cyclase subtype 1 (AC1) KO mice. Furthermore, a selective AC1 inhibitor NB001 blocked pre-LTP in the IC with a dose-dependent manner. Taken together, our results suggest that AC1 contributes to pre-LTP in the IC of adult mice and NB001 may produce anxiolytic effects by inhibiting pre-LTP in the ACC and IC.