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Papers of the Week

Papers: 16 Mar 2019 - 22 Mar 2019

Pharmacology/Drug Development

2019 Mar 18

Curr Pain Headache Rep



The Utilization of Mu-Opioid Receptor Biased Agonists: Oliceridine, an Opioid Analgesic with Reduced Adverse Effects.


Urits I, Viswanath O, Orhurhu V, Gress K, Charipova K, Kaye AD, Ngo A
Curr Pain Headache Rep. 2019 Mar 18; 23(5):31.
PMID: 30880365.


The purpose of this review is to summarize the current understanding of opioid pathways in mediating and/or modulating analgesia and adverse effects. Oliceridine is highlighted as a novel mu-opioid receptor agonist with selective activation of G protein and β-arrestin signaling pathways.