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Papers of the Week

Papers: 16 Mar 2019 - 22 Mar 2019

Pharmacology/Drug Development



Handb Exp Pharmacol


Understanding CGRP and Cardiovascular Risk.


Rubio-Beltrán E, Maassen Van Den Brink A
Handb Exp Pharmacol. 2019; 255:131-140.
PMID: 30879200.


Increasing knowledge about the role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology has led to the development of antibodies against this peptide or its receptor. However, CGRP is widely expressed throughout the body, participating not only in pathophysiological conditions but also in several physiological processes and homeostatic responses during pathophysiological events. Therefore, in this chapter, the risks of long-term blockade of the CGRP pathway will be discussed, with focus on the cardiovascular system, as this peptide has been described to have a protective role during ischemic events, and migraine patients present a higher risk of stroke and myocardial infarction.