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Papers of the Week

Papers: 16 Mar 2019 - 22 Mar 2019

Human Studies

2019 Mar 14

J Transl Med



Exosome microRNA signatures in patients with complex regional pain syndrome undergoing plasma exchange.


Ramanathan S, Douglas SR, Alexander GM, Shenoda BB, Barrett JE, Aradillas E, Sacan A, Ajit SK
J Transl Med. 2019 Mar 14; 17(1):81.
PMID: 30871575.


Therapeutic plasma exchange (PE) or plasmapheresis is an extracorporeal procedure employed to treat immunological disorders. Exosomes, nanosized vesicles of endosomal origin, mediate intercellular communication by transferring cargo proteins and nucleic acids and regulate many pathophysiological processes. Exosomal miRNAs are potential biomarkers due to their stability and dysregulation in diseases including complex regional pain syndrome (CRPS), a chronic pain disorder with persistent inflammation. A previous study showed that a subset of CRPS patients responded to PE.