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Papers of the Week

Papers: 9 Mar 2019 - 15 Mar 2019

Pharmacology/Drug Development


2019 Mar 14

Curr Treat Options Neurol



Invited Commentary on Preventive Anti-Migraine Therapy (PAMT).


Jain S, Silberstein SD
Curr Treat Options Neurol. 2019 Mar 14; 21(4):14.
PMID: 30868470.


Migraine is a chronic paroxysmal neurological disorder characterized by multiphase attacks of head pain and a myriad of neurological symptoms. Chronic migraine causes a great personal and societal burden. Many patients are poorly responsive to, or non-compliant with, conventional migraine preventive therapies. For this reason, physicians are constantly looking for effective migraine prevention strategies. The recent introduction of an innovative pharmacological class useful for migraine prevention, namely monoclonal antibodies towards calcitonin gene-related peptide or its receptors, opens a new, immense therapeutic scenario. In this commentary, the development and efficacy of this novel class of preventive anti-migraine therapy have been discussed and compared with the conventional therapies of migraine prevention.