I am a
Home I AM A Search Login

Papers of the Week

Papers: 9 Mar 2019 - 15 Mar 2019

Animal Studies

2019 May

Ann Rheum Dis



Editor's Pick

Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis.


von Loga IS, El-Turabi A, Jostins L, Miotla-Zarebska J, Mackay-Alderson J, Zeltins A, Parisi I, Bachmann MF, Vincent TL
Ann Rheum Dis. 2019 May; 78(5):672-675.
PMID: 30862648.


Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis (OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a novel vaccine strategy to generate anti-NGF antibodies for reversal of pain behaviour in a surgical model of OA.