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Papers of the Week

Papers: 9 Mar 2019 - 15 Mar 2019

Pharmacology/Drug Development

2019 Aug

Eur J Pain



A Systematic Review and Meta-analysis of Memantine for the Prevention or Treatment of Chronic Pain.


Kurian R, Raza K, Shanthanna H
Eur J Pain. 2019 Aug; 23(7):1234-1250.
PMID: 30848504.


N-methyl-D-aspartate (NMDA) receptors are involved in pain signalling and neuroplasticity. Memantine has been shown to have analgesic properties in pre-clinical and small clinical studies. We conducted a systematic review and meta-analysis to assess the efficacy of memantine to prevent or reduce chronic pain.