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Papers of the Week

Papers: 2 Mar 2019 - 8 Mar 2019

2019 Mar 06




Editor's Pick

Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment.


Tracey I, Woolf CJ, Andrews NA
Neuron. 2019 Mar 06; 101(5):783-800.
PMID: 30844399.


Pain is a subjective sensory experience that can, mostly, be reported but cannot be directly measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural activity, and susceptibility offer the possibility-especially when used in combination-to produce objective pain-related indicators with the specificity and sensitivity required for diagnosis and for evaluation of risk of developing pain and of analgesic efficacy. Such composite biomarkers will also provide improved understanding of pain pathophysiology.