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Papers of the Week

Papers: 2 Mar 2019 - 8 Mar 2019


Animal Studies, Pharmacology/Drug Development

2019 Feb 27

Anesth Analg

Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus.


Dai J, Ding Z, Zhang J, Xu W, Guo Q, Zou W, Xiong Y, Weng Y, Yang Y, Chen S, Zhang J-M, Song Z
Anesth Analg. 2019 Feb 27.
PMID: 30829675.


Pain and depression are highly prevalent symptoms in cancer patients. They tend to occur simultaneously and affect each other and share biological pathways and neurotransmitters. In this study, we investigated the roles of microglia in the hippocampus in the comorbidity of bone cancer pain and depressive-like behaviors in an animal model of bone cancer pain.