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Papers of the Week
ERRFI1 Inhibits Proliferation and Inflammation of Nucleus Pulposus and is Negatively Regulated by miR-2355-5p in Intervertebral Disc Degeneration.
Abstract
MINI: We identified the up-regulation of miR-2355-5p and down-regulation of ERFFI1 in IVDD samples and LPS-treated NP cells. ERFFI1 inhibited NP cells proliferation and LPS-induced pro-inflammatory cytokine production. MiR-2355-5p targeted ERFFI1 and negatively regulated ERFFI1 expression. MiR-2355-5p regulated IVDD by targeting ERFFI1.