I am a
Home I AM A Search Login

Papers of the Week

2019 Aug 01

Spine (Phila Pa 1976)



ERRFI1 Inhibits Proliferation and Inflammation of Nucleus Pulposus and is Negatively Regulated by miR-2355-5p in Intervertebral Disc Degeneration.


Guo Y, Tian L, Liu X, He Y, Chang S, Shen Y
Spine (Phila Pa 1976). 2019 Aug 01; 44(15):E873-E881.
PMID: 30817728.


MINI: We identified the up-regulation of miR-2355-5p and down-regulation of ERFFI1 in IVDD samples and LPS-treated NP cells. ERFFI1 inhibited NP cells proliferation and LPS-induced pro-inflammatory cytokine production. MiR-2355-5p targeted ERFFI1 and negatively regulated ERFFI1 expression. MiR-2355-5p regulated IVDD by targeting ERFFI1.