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Papers of the Week

2019 Apr

Nat Prod Bioprospect



Two New Eudesmane Sesquiterpenoids from the Flowers of Chrysanthemum indicum.


Yang J-L, Liu L-L, Shi Y-P
Nat Prod Bioprospect. 2019 Apr; 9(2):145-148.
PMID: 30820878.


The flowers of Chrysanthemum indicum, i.e. Ye-ju-hua recorded in the Chinese Pharmacopoeia, has been widely used in China as an important heat-clearing and detoxifying herb for the treatment of inflammation, headache, and vertigo. A phytochemical investigation of this herb has led to the isolation of two new eudesmane sesquiterpenoids, 7-epi-eudesm-4(15),11(13)-diene-1β,3β-diol (1) and 7-epi-1β-hydroxy-β-eudesmol (2). The molecular structures of these new sesquiterpenoids were established based on the comprehensive spectroscopic analyses, including NMR, MS, and IR, and comparing with the literatures.