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Papers of the Week

Papers: 23 Feb 2019 - 1 Mar 2019

Animal Studies

2019 Jan-Dec

Mol Pain


Altered glial glutamate transporter expression in descending circuitry and the emergence of pain chronicity.


Guo W, Imai S, Zou S, Yang J, Watanabe M, Wang J, Dubner R, Wei F, Ren K
Mol Pain. 2019 Jan-Dec; 15:1744806918825044.
PMID: 30799685.


The glutamate type 1 transporter (GLT1) plays a major role in glutamate homeostasis in the brain. Although alterations of GLT1 activity have been linked to persistent pain, the significance of these changes is poorly understood. Focusing on the rostral ventromedial medulla, a key site in pain modulation, we examined the expression and function of GLT1 and related transcription factor kappa B-motif binding phosphoprotein (KBBP) in rats after adjuvant-induced hind paw inflammation.