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Papers of the Week

Papers: 23 Feb 2019 - 1 Mar 2019

Animal Studies, Pharmacology/Drug Development

2020 Feb

Anesth Analg



Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema.


Das V, Kroin JS, Moric M, McCarthy RJ, Buvanendran A
Anesth Analg. 2020 Feb; 130(2):525-534.
PMID: 30801357.


Metformin, an adenosine monophosphate (AMP)-activated protein kinase activator, as well as a common drug for type 2 diabetes, has previously been shown to decrease mechanical allodynia in mice with neuropathic pain. The objective of this study is to determine if treatment with metformin during the first 3 weeks after fracture would produce a long-term decrease in mechanical allodynia and improve a complex behavioral task (burrowing) in a mouse tibia fracture model with signs of complex regional pain syndrome.