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Papers of the Week

Papers: 23 Feb 2019 - 1 Mar 2019

Animal Studies

2019 May 15

Physiol Behav


Voluntary biting behavior as a functional measure of orofacial pain in mice.


Guo W, Zou S, Mohammad Z, Wang S, Yang J, Li H, Dubner R, Wei F, Chung M-K, Ro JY, Ren K
Physiol Behav. 2019 May 15; 204:129-139.
PMID: 30797813.


Pain-related behavior secondary to masticatory function can be assessed with the rodent bite force model. A reduction of the bite force has been shown to be related to pain associated with the masseter muscle and jaw activity, while an increase in bite force suggests improvement of muscle function and less pain. To evaluate the usefulness of the bite force measure in studying long-lasting orofacial pain we analyzed biting parameters during prolonged myofascial pain induced by ligation injury of the masseter muscle tendon (TL) in mice.