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Papers of the Week

2019 Feb

Bull Exp Biol Med



Analgesic Activity of Hexaazaisowurtzitane Derivatives.


Krylova SG, Povet'eva TN, Zueva EP, Suslov NI, Amosova EN, Razina TG, Lopatina KA, Rybalkina YO, Nesterova YV, Afanas'eva OG, Kiseleva EA, Sysolyatin SV, Kulagina DA, Zhdanov VV
Bull Exp Biol Med. 2019 Feb; 166(4):461-465.
PMID: 30788739.


Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,0,0] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (acetic acid writhing test). In these experimental models, naloxone-sensitive thiowurtzine-induced analgesia was revealed. The absence of tropism to peripheral opioid receptors in the acetic acid writhing test was demonstrated using naloxone methiodide. Course administration of low-toxic thiowurtzine in effective doses was not associated with ulcerogenic damage to the gastric mucosa in experimental animals.