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Papers of the Week

Papers: 9 Feb 2019 - 15 Feb 2019

Animal Studies

2019 Feb 12

J Neuroinflammation



AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression.


Xiang H-C, Lin L-X, Hu X-F, Zhu H, Li H-P, Zhang R-Y, Hu L, Liu W-T, Zhao Y-L, Shu Y, Pan H-L, Li M
J Neuroinflammation. 2019 Feb 12; 16(1):34.
PMID: 30755236.


Chronic pain is a major clinical problem with limited treatment options. Previous studies have demonstrated that activation of adenosine monophosphate-activated protein kinase (AMPK) can attenuate neuropathic pain. Inflammation/immune response at the site of complete Freund's adjuvant (CFA) injection is known to be a critical trigger of the pathological changes that produce inflammatory pain. However, whether activation of AMPK produces an analgesic effect through inhibiting the proinflammatory cytokines, including interleukin-1β (IL-1β), in inflammatory pain remains unknown.