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Papers of the Week

Papers: 9 Feb 2019 - 15 Feb 2019

Human Studies, Pharmacology/Drug Development

2019 02 12




Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial.


Thybo K H, Hägi-Pedersen D, Dahl J B, Wetterslev J, Nersesjan M, Jakobsen J C, Pedersen N A, Overgaard S, Schrøder HM, Schmidt H, Bjørck J G, Skovmand K, Frederiksen R, Buus-Nielsen M, Sørensen C V, Kruuse L S, Lindholm P, Mathiesen O
JAMA. 2019 02 12; 321(6):562-571.
PMID: 30747964.


Multimodal postoperative analgesia is widely used but lacks evidence of benefit.