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Papers of the Week

Papers: 9 Feb 2019 - 15 Feb 2019

Animal Studies

2019 Feb 08

J Neuroinflammation



TNF-α/STAT3 pathway epigenetically upregulates Nav1.6 expression in DRG and contributes to neuropathic pain induced by L5-VRT.


Ding H-H, Zhang S-B, Lv Y-Y, Ma C, Liu M, Zhang K-B, Ruan X-C, Wei J-Y, Xin W-J, Wu S-L
J Neuroinflammation. 2019 Feb 08; 16(1):29.
PMID: 30736806.


Studies showed that upregulation of Nav1.6 increased the neuronal excitability and participated in neuropathic pain in the dorsal root ganglion (DRG). However, the molecular mechanisms underlying Nav1.6 upregulation were not reported yet.