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Papers of the Week

Papers: 9 Feb 2019 - 15 Feb 2019

2019 Feb 06




Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously.


Navratilova E, Porreca F
Neuron. 2019 Feb 06; 101(3):353-355.
PMID: 30731054.


How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neural and immune systems and offers new approaches for neuroinflammatory therapeutics.