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Papers of the Week

Papers: 9 Feb 2019 - 15 Feb 2019

2019 May

Eur J Pain



The Importance of being specific.


Lopez Garcia J A
Eur J Pain. 2019 May; 23(5):845-846.
PMID: 30735280.


In this issue, you will find a paper by Vasović et al., entitled "Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6GABAA receptors" (D. Vasović et al., 2019). Loss of GABA-mediated inhibition within pain circuits is one of the mechanisms commonly invoked to explain allodynia and hyperalgesia following injury. Intrathecal administration of picrotoxin produces pain like signs. Positive allosteric modulators of GABA receptors like benzodiazepines are known to produce analgesia although their main effects are sedative, hypnotic and anxiolytic and therefore their use as analgesics is curtailed (Schliessbach et al., 2017). This article is protected by copyright. All rights reserved.