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Papers of the Week

Papers: 26 Jan 2019 - 1 Feb 2019

Pharmacology/Drug Development

2019 Jul 08

Annu Rev Neurosci


Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics.


Dib-Hajj SD, Waxman SG
Annu Rev Neurosci. 2019 Jul 08; 42:87-106.
PMID: 30702961.


Acute pain is adaptive, but chronic pain is a global challenge. Many chronic pain syndromes are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons. Current treatments are ineffective or only partially effective and in some cases can be addictive, underscoring the need for better therapies. Molecular genetic studies have now linked multiple human pain disorders to voltage-gated sodium channels, including disorders characterized by insensitivity or reduced sensitivity to pain and others characterized by exaggerated pain in response to normally innocuous stimuli. Here, we review recent developments that have enhanced our understanding of pathophysiological mechanisms in human pain and advances in targeting sodium channels in peripheral neurons for the treatment of pain using novel and existing sodium channel blockers. Expected final online publication date for the Annual Review of Neuroscience Volume 42 is July 8, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.