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Papers of the Week

Papers: 26 Jan 2019 - 1 Feb 2019

Pharmacology/Drug Development

2019 Mar 20

ACS Chem Neurosci



T-Type Channel Druggability at a Crossroads.


Weiss N, Zamponi GW
ACS Chem Neurosci. 2019 Mar 20; 10(3):1124-1126.
PMID: 30697997.


Low-voltage activated T-type calcium channels mediate essential functions in the nervous system, and alteration of channel activity is causally linked to a number of neurological conditions. Therefore, T-type channels hold great promise as pharmacological targets for new medicines. In this Viewpoint, we discuss the potential of T-type channels as druggable targets and reevaluate the strategies available for developing therapeutically efficient and specific modulators of this channel.