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Papers: 26 Jan 2019 - 1 Feb 2019
Pharmacology/Drug Development
2019 Mar 20
ACS Chem Neurosci
10
3
Low-voltage activated T-type calcium channels mediate essential functions in the nervous system, and alteration of channel activity is causally linked to a number of neurological conditions. Therefore, T-type channels hold great promise as pharmacological targets for new medicines. In this Viewpoint, we discuss the potential of T-type channels as druggable targets and reevaluate the strategies available for developing therapeutically efficient and specific modulators of this channel.