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Papers of the Week

Papers: 26 Jan 2019 - 1 Feb 2019

Animal Studies

2019 Feb 06




Editor's Pick

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain.


Green DP, Limjunyawong N, Gour N, Pundir P, Dong X
Neuron. 2019 Feb 06; 101(3):412-420.e3.
PMID: 30686732.


Mast cells can be found in close proximity to peripheral nerve endings where, upon activation, they release a broad range of pro-inflammatory cytokines and chemokines. However, the precise mechanism underlying this so-called neurogenic inflammation and associated pain has remained elusive. Here we report that the mast-cell-specific receptor Mrgprb2 mediates inflammatory mechanical and thermal hyperalgesia and is required for recruitment of innate immune cells at the injury site. We also found that the neuropeptide substance P (SP), an endogenous agonist of Mrgprb2, facilitates immune cells' migration via Mrgprb2. Furthermore, SP activation of the human mast cell led to the release of multiple pro-inflammatory cytokines and chemokines via the human homolog MRGPRX2. Surprisingly, the SP-mediated inflammatory responses were independent of its canonical receptor, neurokinin-1 receptor (NK-1R). These results identify Mrgprb2/X2 as an important neuroimmune modulator and a potential target for treating inflammatory pain.