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Papers of the Week

2019 Jan 23

BMC Med Res Methodol



Migraine day frequency in migraine prevention: longitudinal modelling approaches.


Di Tanna G L, Porter JK, Lipton RB, Brennan A, Palmer S, Hatswell AJ, Sapra S, Villa G
BMC Med Res Methodol. 2019 Jan 23; 19(1):20.
PMID: 30674285.


Health economic models are critical tools to inform reimbursement agencies on health care interventions. Many clinical trials report outcomes using the frequency of an event over a set period of time, for example, the primary efficacy outcome in most clinical trials of migraine prevention is mean change in the frequency of migraine days (MDs) per 28 days (monthly MDs [MMD]) relative to baseline for active treatment versus placebo. Using these cohort-level endpoints in economic models, accounting for variation among patients is challenging. In this analysis, parametric models of change in MMD for migraine preventives were assessed using data from erenumab clinical studies.