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Papers of the Week

Papers: 19 Jan 2019 - 25 Jan 2019

Human Studies

2019 Apr

Clin J Pain



TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers.


Weyer-Menkhoff I, Lötsch J
Clin J Pain. 2019 Apr; 35(4):321-327.
PMID: 30664549.


Transient receptor potential ion channels play a role in thermal hyperalgesia and are among targets of novel analgesics. However, a role of TRPA1 in either heat or cold hyperalgesia is controversial. In this study, changes in thermal sensitivity were assessed following topical application of a specific sensitizer of TRPA1 and compared with the effects of sensitizers of TRPV1 and TRPM8.