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Papers of the Week

Papers: 5 Jan 2019 - 11 Jan 2019

Animal Studies, Pharmacology/Drug Development

2019 Mar

Biochem Pharmacol


Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system.


Salaga M, Binienda A, Piscitelli F, Mokrowiecka A, Cygankiewicz AI, Verde R, Malecka-Panas E, Kordek R, Krajewska WM, Di Marzo V, Fichna J
Biochem Pharmacol. 2019 Mar; 161:37-51.
PMID: 30611738.


Molecular basis of abdominal pain in IBD is not fully characterized. Serotonin (5-HT) increases visceral pain severity and contributes to exacerbation of inflammation. Moreover, it is well established that decreased anandamide (AEA) signaling in the gut increases visceral pain severity. The aim of this study was to investigate the interplay between 5-HT and endocannabinoid signaling in colitis.