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Papers of the Week

Papers: 29 Dec 2018 - 4 Jan 2019

Animal Studies

2019 Jan 03

BMC Neurosci



Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.


Roa-Coria J E, Pineda-Farias J B, Barragán-Iglesias P, Quiñonez-Bastidas G N, Zúñiga-Romero Á, Huerta-Cruz J C, Reyes-García J G, Flores-Murrieta F J, Granados-Soto V, Rocha-González H I
BMC Neurosci. 2019 Jan 03; 20(1):1.
PMID: 30602386.


Peripheral diabetic neuropathy can be painful and its symptoms include hyperalgesia, allodynia and spontaneous pain. Hydrogen sulfide (HS) is involved in diabetes-induced hyperalgesia and allodynia. However, the molecular target through which HS induces hyperalgesia in diabetic animals is unclear. The aim of this study was to determine the possible involvement of transient receptor potential (TRP) channels in HS-induced hyperalgesia in diabetic rats.