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Galcanezumab treatment changes visual related EEG connectivity patterns in migraine patients.

Monoclonal antibodies against calcitonin gene-related peptides (CGRP) are innovative therapies for migraine treatment. Although they are clinically effective, how anti-CGRP treatment reduces migraine attacks still remains unclear.

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MR-guided high-intensity focused ultrasound for chronic pain: Where do we stand?

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Altered resting-state effective connectivity of trigeminal vascular system in migraine without aura: A spectral dynamic causal modeling study.

The trigeminal vascular system is an important part of the anatomical and physiological basis of migraine. The effective connectivity (EC) among the regions of interest (ROIs) in the trigeminal vascular […]

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Mapping Brain Structure Variability in Chronic Pain: The Role of Widespreadness and Pain Type and its Mediating Relationship with Suicide Attempt.

Chronic pain affects nearly 20% of the US population. It is a leading cause of disability globally, and associated with a heightened risk for suicide. The role of the central […]

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TSPO PET brain inflammation imaging: A transdiagnostic systematic review and meta-analysis of 156 case-control studies.

The 18-kDa translocator protein (TSPO) is increasingly recognized as a molecular target for PET imaging of inflammatory responses in various central nervous system (CNS) disorders. However, the reported sensitivity and […]

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Brain-predicted age difference estimated using DeepBrainNet is significantly associated with pain and function-a multi-institutional and multiscanner study.

Brain age predicted differences (brain-PAD: predicted brain age minus chronological age) have been reported to be significantly larger for individuals with chronic pain compared with those without. However, a debate […]

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Preoperative resting-state microstate as a marker for chronic pain after breast cancer surgery.

Chronic postoperative pain poses challenges, emphasizing the importance of accurately predicting pain in advance. Generally, pain perception is associated with the temporal dynamics of the brain, which can be represented […]

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Meningeal P2X7 signaling mediates migraine-related intracranial mechanical hypersensitivity.

Cortical spreading depolarization (CSD) is a key pathophysiological event that underlies visual and sensory auras in migraine. CSD is also thought to drive the headache phase in migraine by promoting […]

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Insights into migraine attacks from neuroimaging.

Migraine is one of the most common neurological diseases and it has a huge social and personal impact. Although head pain is the core symptom, individuals with migraine can have […]

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Abnormal glutamatergic and serotonergic connectivity in visual snow syndrome and migraine with aura.

Neuropharmacological changes in visual snow syndrome (VSS) are poorly understood. We aimed to use receptor target maps combined with resting fMRI data to identify which neurotransmitters might modulate brain circuits […]

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