Rejected

To investigate the inhibitory effect of ANA-12 that blocks brain-derived neurotrophic factor (BDNF)/ tropomyosin receptor kinase B (TrkB) signaling on inflammatory pain in rats and explore the underlying mechanism.

Migraine is a headache disorder with the highest socioeconomic burden. The aim of this study was to deliver the first proof-of-concept data of the potential role of an individual low-glycemic diet provided by a novel digital health application in the prophylaxis of migraine.

The 2014 Time-Use Survey of Statistics Korea revealed that office workers are increasingly spending more than eight hours at work. This study conducted an exposure assessment for office workers in Korea. Indoor and outdoor air pollutants were measured in offices. A self-administered questionnaire was employed to determine work information, indoor air quality (IAQ) awareness, and subjective symptoms for 328 workers. Indoor air concentrations for measured air pollutants were below IAQ guideline values. The average concentrations of target air pollutants did not show significant differences except for benzene, which had relatively a higher concentration in national industrial complexes. The indoor benzene, ethylbenzene, and acetaldehyde concentrations were higher in offices where workers were having dry eye, ophthalmitis, and headache symptoms. This study provides reference values to manage IAQ in offices, suggesting that if the benzene concentration exceeds 4.23 μg/m in offices, it could cause dry eye symptoms. Considering the increasing working hours for office workers and health effects, workers' exposure to indoor pollutants should be reduced. In addition, the IAQ was heavily influenced by outdoor air levels and various indoor sources. Therefore, in areas with relatively high air pollution, greater monitoring and management is required considering the influence of outdoor air quality.

Mild encephalitis/encephalopathy with reversible splenial lesion is a clinical-radiological entity found to occur in the setting of an acute systemic inflammatory state with isolated lesions of the splenium of the corpus callosum and mild encephalopathy. Mild encephalitis/encephalopathy with reversible splenial lesion is commonly found to occur in children in the setting of viral infections. It has rarely been associated with Mycoplasma pneumoniae in the United States, unlike in Eastern and Southern Asia where this is much more prominent.

Splenosis is the heterotopic autotransplantation of splenic tissue after severe splenic trauma and/or splenectomy. The epidemiology is elusive, but splenosis is frequently misdiagnosed as malignant tumors of gastrointestinal, gynecological, or hematological origin before the correct diagnosis is ultimately found. We herein report a rare case of combined, extensive intraabdominal and intrathoracic splenosis initially presenting as pleural mesothelioma.

Pectus excavatum and pectus carinatum are the most common chest wall deformities of childhood. Surgical repair can be complicated by post-operative analgesic challenges. Thoracic epidural analgesia, patient-controlled analgesia, and multimodal pain control are among the most common strategies. We sought to define the current utilization of intraoperative thoracic neurolysis, hypothesizing that this would minimize length of stay (LOS) and post-operative narcotic use with relatively higher proportion of non-narcotic post-operative analgesia.

The role of TRPA1 receptor channels in meningeal nociception underlying the generation of headaches is still unclear. Activating as well as inhibitory effects of TRPA1 agonists have been reported in animal models of headache. The aim of the present study was to clarify the effect of the TRPA1 agonist nitroxyl (HNO) delivered by Angeli's salt in two rodent models of meningeal nociception. Single fibre recordings were performed using half-skull preparations of mice (C57BL/6) in vitro. Angeli's salt solution (AS, 300 µM) caused short-lasting vigorous increases in neuronal activity of primary meningeal afferents, followed by deactivation and desensitisation. These effects were similar in TRPA1 knockout and even more pronounced in TRPA1/TRPV1 double-knockout mice in comparison to wild-type mice. The activity of spinal trigeminal neurons with afferent input from the dura mater was recorded in vivo in anesthetised rats. AS (300 µM) or the TRPA1 agonist acrolein (100 and 300 µM) was applied to the exposed dura mater. AS caused no significant changes in spontaneous activity, while the mechanically evoked activity was reduced after acrolein application. These results do not confirm the assumption that activation of trigeminal TRPA1 receptor channels triggers the generation of headaches or contributes to its aggravation. Instead, there is evidence that TRPA1 activation may have an inhibitory function in the nociceptive trigeminal system.

Though quinoline anti-infective agents-associated neurotoxicity has been reported in the early 1970s, it only recently received regulatory recognition. In 2019, the European Medicines Agency enforced strict use for quinoline antibiotics. Thus, the current study evaluates the relation between subacute exposure to diiodohydroxyquinoline (DHQ), a commonly misused amebicide, with the development of motor and sensory abnormalities, highlighting age and gender as possible predisposing factors. Eighty rats were randomly assigned to eight groups according to their gender, age, and drug exposure; namely, four control groups received saline (adult male, adult female, young male, and young female), and the other four groups received DHQ. Young and adult rats received DHQ in doses of 176.7 and 247.4 mg/kg/day, respectively. After 4 weeks, rats were tested for sensory abnormality using analgesiometer, hot plate, and hind paw cold allodynia tests, and for motor function using open field and rotarod tests. Herein, the complex behavioral data were analyzed by principal component analysis to reduce the high number of variables to a lower number of representative factors that extracted components related to sensory, motor, and anxiety-like behavior. Behavioral outcomes were reflected in a histopathological examination of the cerebral cortex, striatum, spinal cord, and sciatic nerve, which revealed degenerative changes as well demyelination. Noteworthy, young female rats were more susceptible to DHQ's toxicity than their counterparts. Taken together, these findings confirm previous safety concerns regarding quinoline-associated neurotoxicity and provide an impetus to review risk/benefit balance for their use.

Despite the public health concern, there is a dearth of research regarding perceived noise pollution and noise-related health status in Bangladesh. This study was carried out to evaluate the noise-related health status among Bangladesh's adult population. 1386 adult Bangladeshis participated in an online survey. A linear regression model was used to evaluate overall noise-related health status determinants. 91% of the survey population reported noisy environments in their neighborhood, with the majority reporting two types (34%) of noise pollution sources. Road vehicles (38%) and construction activities (24%) were identified as significant source of noise pollution. The Bangladeshis are primarily exposed to noise during school and office hours. Socio-demographic information, perceived noise pollution and individual views towards noise pollution were examined as determinants of noise-related health problems. Females were found to be more impacted than males, and young people also expressed concern about noise pollution's influence. Residents in mixed-unit buildings exhibited a significant level of noise-related health problems such as deafness, insomnia, heart disease, headache, stress, poor concentration, production loss, fatigue, irritability, heartburn, indigestion, ulcers, and high blood pressure. Noise pollution from road vehicles and industry has been shown to have a negative effect on people's health. Individuals affected by noise were interested in noise reduction efforts. The findings of this research may aid in the improvement of international, national, and local noise control efforts.

Proper evaluation of ocular fundi is an integral part of neurological examination. Unfortunately, neurology residents are increasingly uncomfortable performing fundoscopy and interpreting findings because of diminishing skills and lack of experience. This became more prominent during the COVID-19 pandemic as fundoscopy requires proximity to the patient. With the recent dramatic improvement of smartphone cameras, fundus photography using the PanOptic Ophthalmoscope (Welch Allyn, Skaneateles Falls, NY) with a smartphone adapter offered an alternative to direct fundoscopic examination. We present the first experience with our own design of a universal smartphone adapter.