Rejected

White matter alterations in patients with chronic migraine (CM) have been reported. Traditional Chinese medicine (TCM) syndromes are clinical syndromes proposed by TCM doctors based on long-term clinical observation and classification of the clinical symptoms and signs of CM patients. This study aimed to analyze the whole-brain diffusion tensor imaging (DTI) data of CM patients with different types of TCM syndromes. Sixteen CM patients diagnosed with liver-yang hyperactivity (LH) syndrome and 16 CM patients with qi-blood deficiency (QD) syndrome were recruited in this study. Thirty-one healthy controls (HCs) were also enrolled. All subjects underwent DTI and T1-weighted MRI acquisition. Thirty HCs and 30 CM patients (LH group: n = 15; QD group: n = 15) were included in the final analysis. No significant difference was observed in the DTI indexes between CM patients and HCs, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). The mean FAs of the left tapetum and the mean MD values for the right medial lemniscus and the right inferior cerebellar peduncle were significantly different in the LH and HC groups. The mean AD values for the right cingulate gyrus and the left uncinate fasciculus, as well as the mean RD for the right inferior cerebellar peduncle and the left tapetum, were also significantly different between these two groups. CM patients with LH and QD syndrome showed altered FA and diffusivity in comparison to healthy controls, suggesting that there may be significant white matter microstructural alterations in these patients.

To assess women's positive and negative perceptions after giving birth. The secondary objectives were to identify the women who had a negative perception of their delivery, define the risk factors, and propose actions that maternity units can take to improve their management.

The present study aimed to investigate the expression of mRNA in the brachial plexus avulsion neuropathic pain model and analyze biological functions. Microarray mRNA assay and reverse transcriptase quantitative polymerase chain reaction (RT-PCR) were conducted. The whole blood was collected from two groups for Microarray mRNA analysis. The predicted mRNA targets were studied by gene ontology analysis and pathway analysis. We identified 3 targeted mRNAs, including PIK3CB, HRAS, and JUN. The results showed that PIK3CB, HRAS, and JUN gene expression was increased in the control group but decreased in the neuropathic pain group. These findings indicate that certain genes may be important biomarkers for the potential targets for the prevention and treatment of brachial plexus avulsion caused neuropathic pain.

There is increasing evidence that inflammation plays a role in the pathogenesis of aneurysmal subarachnoid hemorrhage (aSAH) and in the development of delayed cerebral ischemia (DCI). However, the assessment and interpretation of classically defined inflammatory parameters is difficult in aSAH patients. The objective of this study was to investigate the relationship between easily assessable findings (hyperventilation, fever, white blood cell count (WBC), and C-reactive protein (CRP)) and the occurrence of DCI and unfavorable neurological outcome at discharge in aSAH patients.

Ankle sprains result in pain and disability. While factors such as body mass and prior injury contribute to subsequent injury, the association of the number of ankle sprains on body anthropometrics and self-reported function are unclear in this population. Therefore, the purpose of this investigation was to assess differences in anthropometric measurements and self-reported function between the number of ankle sprains utilizing a large, pooled data set.

Microdeletion in the 16p11.2 loci lead to a distinct neurodevelopmental disorder with intellectual disability and autism spectrum disorder in addition to dysmorphia, macrocephaly and increased body mass index (BMI). One of the deleted genes in this region is PRRT2 which codes for Proline-rich transmembrane protein 2. Heterozygous variants in PRRT2 cause four distinct neurological disorders including Benign Familial Infantile Epilepsy (BFIE), Paroxysmal Kinesigenic Dyskinesia (PKD), PKD with Infantile Convulsions (PKD/ IC) and Familial Hemiplegic Migraine (FHM). A 13-year-old male with a known history of 16p11.2 deletion and resultant cognitive delay presented with sudden onset of headache, left sided weakness, facial droop and aphasia concerning for acute ischemic stroke. Magnetic Resonance Imaging (MRI) of the brain was performed urgently which did not reveal any acute processes and his presentation met criteria for hemiplegic migraine. There have been reports of PKD and BFIE in this microdeletion syndrome however, our proband is the first case that presented with FHM related to haploinsufficiency of PRRT2. This report highlights the importance of counselling patient families regarding acute paroxysmal presentations in this syndrome.

Pain and sensory disturbances are common side effects of breast cancer treatment. Differential somatosensory functioning may reflect distinct pathophysiological backgrounds and therapeutic needs. Aim was to examine whether questionnaires evaluating signs and symptoms related to somatosensory functioning correlate sufficiently with quantitative sensory testing (QST) in breast cancer survivors to warrant consideration for somatosensory profiling in clinical practice.

Neurocutaneous melanosis (NCM) is a rare congenital, nonhereditary neurocutaneous syndrome that mainly occurs in children; adult NCM is very rare. Due to its rarity, the clinical features and treatment strategies for NCM remain unclear. The purpose of this study was to explore the clinical features, diagnosis, treatment and prognosis of NCM in adults. Most intracranial meningeal melanomas are solid masses, and cystic-solid malignant melanomas are very rare. Due to the lack of data, the cause of cystic changes and the effect on prognosis are unknown.

An erratum was issued for: Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model. The Protocol and Discussion sections were updated. Step 3.5 was updated from: Clean the right femoral area with surgical soap and antiseptic povidone-iodine solution under sterile conditions to: Clean the right femoral area with surgical soap followed by alternating antiseptic povidone-iodine solution and alcohol 3 times under sterile conditions. Section 9 was updated from: 9. Euthanasia method Under previous sedation and anesthesia, as previously described, administer an IV sodium thiopental overdose (200 mg/kg). Confirm cardiorespiratory arrest and death by monitoring vital signs (electrocardiogram, blood pressure, capnography). to: 9. Postoperative pain assessment and monitoring During the post-surgical follow-up, monitor the general condition of the animals, including the respiratory rate, food and water intake, activity and interaction with the other individuals, appearance and coloration of the skin, and the evolution of the surgical wound. Apply a daily supervision protocol according to the following scoring criteria: – Weight: 0: Normal 1: <10% weight loss 2: 10-20% weight loss 3:> 20% weight loss – Body condition: 0: Good: non-prominent vertebrae, pelvic or spinal bones 2: Regular: evidence of spinal segmentation, palpable pelvic bones 3: Emaciation: extremely marked skeleton, little or no meat to cover – Behavior: 0: Normal: Active and interactive in your environment 1: Slight decline in activity and less interactive 2: Abnormal: pronounced decline in activity, isolated 3: Abnormal: Immobile or hyperactivity, possible self-harm – Physical appearance: 0: Normal: skin/hair shiny and eyes bright 1: Disappears embalming, skin/hair without shine 2: Poor skin/nasal secretions 3: Poor skin, abnormal or hunched posture – Behavioral disorders: 0: None 1: Inability to move normally 2: Unable to reach food/drink, isolated from other animals 3: Intention to hide/corner, does not respond to stimuli (dying) – Clinical signs: 0: None 1: Hypothermia, fever, mild respiratory failure 2: Infection of the surgical wound, moderate respiratory failure with muco-bloody secretions 3: Heart failure, severe respiratory failure (cyanosis, open mouth) Score: – 1-5: Supervise the animals once a day. – 6-12: Provide supportive therapy if necessary. – Any animal with a score of 3 in any of the above parameters or with a total score >12 will be euthanized. NOTE: The animals should be monitored daily by the animal care staff and twice a week by the research and veterinary team. Although no pain and distress are expected from the procedure, if any animal shows signs of pain, give analgesic therapy (tramadol, oral, 2-4 mg/kg, daily). If any animal does not respond to analgesic medication and shows signs of chronic pain (very low probability), euthanize the animal with an anesthetic overdose (sodium thiopental, IV, 200 mg/kg). If the surgical wound shows signs of infection (low probability) despite the antibiotic therapy administered, treat the wound daily and initiate a new antibiotic regimen (cefquinome sulphate, IM, 2 mg/kg, daily). 10. Euthanasia method Under previous sedation and anesthesia, as previously described, administer an IV sodium thiopental overdose (200 mg/kg). Confirm cardiorespiratory arrest and death by monitoring vital signs (electrocardiogram, blood pressure, capnography).