Rejected

This post hoc analysis assessed efficacy and safety of intravenous (IV) golimumab in ankylosing spondylitis (AS) patients with early disease (ED) versus late disease (LD).

Retrospective study.

We compared the long-term health of adults with prior Kawasaki disease (KD) to controls and determined whether outcomes varied by coronary artery (CA) status.

To report a novel case of bilateral anterior and posterior scleritis in a patient with acute myelogenous leukemia (AML).

Endometriosis is a chronic inflammatory disorder with a prevalence of six to ten percent in women of childbearing age. As long as the aetiology of endometriosis is not fully understood and the disease has no definitive treatment, an examination of the environmental factors or interventions that could modify or cure endometriosis would greatly benefit women suffering from this chronic condition. This literature review utilized the electronic databases PubMed, EMBASE, and MEDLINE until February 2021. Studies indicate that fish oil may have a positive effect on reducing endometriosis-related pain due to the effects of pro-inflammatory prostaglandins derived from omega-3 fatty acids. The same effect was seen with the introduction of antioxidant vitamins C, D, and E. There is clinical viability of a low fermentable oligo-, di-, and mono-saccharides and polyols diet to successfully reduce the symptoms of patients who suffer from both endometriosis and irritable bowel syndrome. Despite the low level of evidence, there are frequent associations between endometriosis and gastrointestinal conditions in addition to the influence of various nutritional factors on the disease. The management of endometriosis requires a holistic approach focused on reducing overall inflammation, increasing detoxification, and attenuating troublesome symptoms. A dietician may provide great benefit in the management of these patients, especially at younger ages and in early stages. High-level evidence and well-designed randomized studies are lacking when it comes to studying the effect of lifestyle and dietary intake on endometriosis. Inarguably, further research with a more extensive focus is needed.

Pancreatic cancer is the fourth biggest cause of cancer-related fatalities in the World and generally affects people in their sixth to eighth decades. Cigarette smoking, obesity, high alcohol intake and chronic pancreatitis are underlying risk factors. The majority of pancreatic carcinomas are ductal adenocarcinomas, frequently developed on the head of the pancreas. Due to the delayed emergence of clinical symptoms, the pathology is often detected in a late stage (e.g. epigastric pain, painless jaundice and weight loss). When the primary tumor is diagnosed, it has often already advanced to other organs, primarily the liver. Surgical excision is only achievable in around 20 percent of patients, therefore palliative care is generally the sole option. The most prevalent surgical procedure performed is pancreaticoduodenectomy (Whipple procedure). Survival rates at five years vary from 3 to 40% depending on the size, spread and resectability of the tumor. Imaging may sometimes detect tiny, possibly resectable pancreatic lesions. These lesions may be benign, premalignant or malignant. Pancreatic cystic lesions and pancreatic neuroendocrine tumors profit from special medical and surgical treatment. Screening is not conducted frequently, although it is advised for selected, high-risk patients.

The case highlights the importance of specific non-traditional cardiovascular risk factors in a patient with premature severe cardiovascular disease, despite an apparently adequate control of traditional cardiovascular risk factors.

It is believed that vitamin B12 deficiency and hyperhomocysteinemia cause endothelial cell damage by increasing the levels of free oxygen radicals, which may, in turn, be related to the onset of migraine episodes.

Spontaneous intracranial hypotension (SIH) is an infrequent cause of daily persistent orthostatic headache with an incidence of 5 to 100,000 persons/year. In very rare cases, no cause can be found and these conditions may be called spontaneous cerebrospinal fluid leak (CSFL). Radionuclide cisternography (RNC) has played useful role in detecting CSFL. Although RNC has been used in many cases, few have been reported in which CSFL out of the subarachnoid space was detected. A case of CSFL confirmed by RNC direct findings is reported. SIH is difficult to diagnose and 95% of patients may initially receive an incorrect diagnosis. RNC has been shown to be fairly characteristic in SIH patients.