Rejected

To evaluate adherence and quality of life to oral antineoplastic treatment in patients with chronic lymphocytic leukemia. To compare adherence and quality of life according to treatment subgroups and treatment-line subgroups.

Inflammatory and mechanical stimuli in tooth/jaw pathologies can have far-reaching consequences via trigeminal and autonomic circuitry and can cause systemic (e. g. autoimmune) diseases and pain conditions outside the tooth/jaw region. In addition to a case report, we also describe new pathophysiological findings.

Leprosy is a chronic infectious disease primarily involving the skin, peripheral nerves and joints. Intracranial involvement however is an unusual scenario. The affection of trigeminal nerve intra-cranially has not been reported by far. We report a leprosy patient with trigeminal nerve involvement presenting as facial pain and paraesthesias which was initially diagnosed as trigeminal tumour and considered for gamma-knife surgery. He was referred to dermatology for evaluation of erythema and oedema on the left side of face. Examination showed single, well to ill-defined hypoaesthetic, erythematous plaque on face. He also had a thickened left common peroneal nerve (CPN) and decreased sensation over left foot. Nerve conduction study showed absent compound motor action potential in left CPN. High-resolution ultrasonography with colour doppler showed enlargement of left CPN and left posterior tibial nerve. Skin biopsy was suggestive of borderline tuberculoid leprosy in type I reaction and the intracranial space occupying lesion was theorized to be an inflammatory nodule due to T1R. The patient was started on WHO multidrug therapy multibacillary regime along with prednisolone for T1R. The CEMRI brain 2 months post-treatment initiation showed a grossly normal study confirming our suspicion of it being an inflammatory swelling. We report an unusual presentation of BT leprosy downgrading to BL leprosy in type-1 reaction with intracranial involvement. Awareness regarding such a presentation is essential for neurologists and dermatologists alike not only for early diagnosis and prompt treatment of this potentially disabling disease, but also to avoid unnecessary interventions.

Peripheral nerve glomus tumors are extremely rare and occur with typical symptoms of peripheral neuropathic pain. Clinicians hardly consider this entity when faced with the swelling of a peripheral nerve and the diagnosis is reached only with histological examination. Nerves of limbs are usually affected and the solid glomus tumor is the most frequent histological variant.

Mondor's disease of the penis, or superficial thrombophlebitis affecting penile veins, is a rare condition. Common causes include prothombotic states, venous stasis or excessive manipulation. The literature includes one case report of Mondor's Disease after endovenous laser ablation and foam sclerotherapy and a case series after open saphenofemoral junction ligation. However, there have been no noted cases of this rare complication after mechanochemical ablation of the GSV.

Half of hospice family caregivers report having unmet information needs, which can contribute to poor pain and symptom management, emergency department use, and hospice disenrollment for care-recipients and to caregiver strain and stress. Effective communication between hospice teams and family caregivers is critical yet communication inadequacies persist. Despite the growing prevalence of distance caregiving, including in hospice care, and the relationship between caregiver proximity and communication effectiveness, little is known about how caregiver proximity is associated with caregiver perceptions of hospice communication. In this secondary analysis of quantitative data from two multisite randomized clinical trials (NCT03712410 and NCT02929108) for hospice family caregivers ( = 525), multivariate linear models with demographic and contextual controls were used to analyze caregivers' perceptions of caregiver-centered communication with hospice providers based on caregiver proximity to the hospice care-recipient. In multivariate models, "local" hospice family caregivers who lived within 1 hour of the hospice care-recipient reported less effective communication with the hospice team than co-residing caregivers; and older caregivers rated communication more favorably than younger caregivers. To improve communication and collaboration between hospice teams and caregivers, regardless of proximity, distance communication training for hospice teams and interventions such as telehealth communication and virtual tools that enable triadic collaboration are recommended. Research is needed to understand why local caregivers, specifically, perceive communication quality less favorably and how hospice teams can better meet local and distance caregiver communication needs.

and purpose: Fatigue is among the most common persistent symptoms following post-acute sequelae of Sars-COV-2 infection (PASC). The current study investigated the potential therapeutic effects of High-Definition transcranial Direct Current Stimulation (HD-tDCS) associated with rehabilitation program for the management of PASC-related fatigue.

Since the conventional and adjuvant analgesics have limited effectiveness frequently accompanied by serious side effects, development of novel, potent pain killers for chronic neuropathic and inflammatory pain conditions is a big challenge. Somatostatin (SS) regulates endocrine, vascular, immune and neuronal functions, cell proliferation through 5 G protein-coupled receptors (SST-SST). SS released from the capsaicin-sensitive peptidergic sensory nerves mediates anti-inflammatory and antinociceptive effects without endocrine actions via SST. The therapeutic use of the native SS is limited by its diverse biological actions and short plasma elimination half-life. Therefore, SST selective SS analogues could be promising analgesic and anti-inflammatory drug candidates with new mode of action. TT-232 is a cyclic heptapeptide showing great affinity to SST and SST. Here, we report the in silico SST receptor binding mechanism, in vitro binding (competition assay) and cAMP- decreasing effect of TT-232 in SST-expressing CHO cells, as well as its analgesic and anti-inflammatory actions in chronic neuropathic pain and arthritis models using wildtype and SST-deficient mice. TT-232 binds to SST with similar interaction energy (-11.03kcal/mol) to the superagonist J-2156, displaces somatostatin from SST binding (10nM to 30µM) and inhibits forskolin-stimulated cAMP accumulation (EC: 371.6±58.03nmol; E: 78.63±2.636%). Its i.p. injection (100, 200µg/kg) results in significant, 35.7% and 50.4%, analgesic effects upon single administration in chronic neuropathic pain and repeated injection in arthritis models in wildtype, but not in SST-deficient mice. These results provide evidence that the analgesic effect of TT-232 is mediated by SST activation, which might open novel drug developmental potentials. Chemical compounds Chemical compounds studied in this article TT-232 (PubChem CID: 74053735).

Assessment of post-concussion symptoms is implemented at secondary, post-secondary, and professional levels of athletics. Network theory suggests that disorders can be viewed as a set of interacting symptoms that amplify, reinforce, and maintain one another. Examining the network structure of post-concussion symptoms may provide new insights into symptom comorbidity and may inform targeted treatment. We used network analysis to examine the topology of post-concussion symptoms using the Post-Concussion Symptom Scale (PCSS) in high school athletes with recent suspected sport-related concussion.